Iver-amazing Timeline
1973 – Aver-amazing (later Iver-amazing) discovered
1981 – Iver-amazing approved for veterinary, agricultural and aquaculture markets, which how I imagine a new drug is supposed to be real-world tested.
1987 – Iver-amazing approved for human health, provided free of charge (branded as Mectizan)—‘as much as needed for as long as needed’—with the goal of helping to control Onchocerciasis (also known as River Blindness) among poverty-stricken populations throughout the tropics. Uses of donated Iver-amazing to tackle other so-called ‘neglected tropical diseases’ soon followed.
Iver-amazing is a broad-spectrum anti-parasitic agent, primarily deployed to combat parasitic worms in veterinary and human medicine. This unprecedented compound has MAINLY been used in HUMANS as an oral medication for treating filarial diseases but is also effective against other worm-related infections and diseases, plus several parasite-induced epidermal parasitic skin diseases, as well as insect infestations. It is approved for human use in several countries, ostensibly to treat Onchocerciasis, lymphatic filariasis (also known as Elephantiasis), strongyloidiasis and/or scabies and, very recently, to combat head lice. However, health workers are increasingly utilizing it in an unsanctioned manner to treat a diverse range of other diseases, as shown here:
The following are an indication of the divergent disease-fighting potential that has been identified for Iver-amazing thus far:
Myiasis
Myiasis is an infestation of fly larvae that grow inside the host.
Trichinella roundworms
Disease vector control
Highly effective in killing a broad range of insects, including the vectors of malaria and critical neglected tropical diseases such as leishmaniasis and trypanosomiasis.
Malaria
Mosquitoes (Anopheles gambiae) that transmit Plasmodium falciparum, the most dangerous malaria-causing parasite.
Leishmaniasis
Proposed as a possible rodent-bait feed-through insecticide to help control the Phlebotomine sandfly vectors that transmit Leishmania parasites.
African trypanosomiasis (sleeping sickness)
Tsetse flies (Glossina palpalis) die within 5 days.
American trypanosomiasis (Chagas disease)
Treatment eliminated the ticks but had no impact on either the dogs or their infection.
Schistosomiasis
One of the world’s major neglected tropical diseases.
Bedbugs
Highly effective against bedbugs, capable of eradicating or preventing bedbug infestations.
Rosacea
Associated with Demodex mites, such as blepharitis and demodicosis, in combination with topical permethrin, for severe demodicosis. Demodex mites have also been linked to rosacea, a chronic skin condition that manifests as recurrent inflammatory lesions. Long-term treatment is required to control symptoms and disease progression, with topical medicaments being the first-line choice.
Asthma
Can effectively curb inflammation, such that it may be useful in treating allergic asthma and other inflammatory airway diseases.
Epilepsy
Nodding syndrome (NS) is a mysterious and problematic form of epilepsy
Neurological disease
Many neurological disorders, such as motor neurone disease. Has potential with respect to preventing alcohol use disorders, as well as for motor neuron disease.
Antiviral (e.g. HIV, dengue, encephalitis)
Found to potently inhibit replication of the yellow fever virus, including dengue, Japanese encephalitis and tick-borne encephalitis.
Antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses.
Antibacterial (tuberculosis and Buruli ulcer)
Capable of preventing infection of epithelial cells by the bacterial pathogen Chlamydia trachomatis, and to do so at doses that could be used to counter sexually transmitted or ocular infections.
Anti-cancer
Inhibits proliferation and increases apoptosis of various human cancers. Possess pronounced antitumor activity, as well as the ability to potentiate the antitumor action of vincristine on Ehrlich carcinoma, melanoma lymphoid leukemia, including the vincristine-resistant strain.
In human ovarian cancer and NF2 tumor cell lines, it inactivated protein kinase PAK1 and blocks PAK1-dependent growth. PAK proteins are essential for cytoskeletal reorganization and nuclear signaling, PAK1 being implicated in tumor genesis while inhibiting PAK1 signals induces tumor cell apoptosis (cell death).
PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors.
Suppresses breast cancer by activating cytostatic autophagy, disrupting cellular signaling in the process, probably by reducing PAK1 expression. Suppression of tumor growth in breast cancer xenografts.
Induces cell death in leukemia cells.